A Review on Herbal Antioxidants

Journal: Journal of Pharmacognosy and Phytochemistry

Author: Sangh Partap*, Sanjay pandey

Abstract: The present review is an attempt to highlight the various ethno botanical and traditional uses as well as phytochemical and pharmacological reports onMimusops elengi to which  commonly known as Bakul and Spanish cherry, belonging to Sapotaceae family. It is a large ornamental evergreen tree cultivated in India and generally reared in gardens for the sake of its fragrant flowers. In the traditional Indian system of medicine, the ayurveda and in various folk system of medicine, the bark, fruit and seeds of Mimusops elengi possess several medicinal properties such as astringent, tonic, and febrifuge. Chemical studies have shown that, Bark contain tannin, some caoutchoue, wax, starch and ash and Flower contain volatile oil as well as Seeds contain fixed fatty oil.  Preclinical studies have shown that Mimusops elengior some part of its phytochemicals possess Analgesic, Antibiotic, Antihyperlipidemic, Anti-inflammatory, Antimicrobial, Antoxidant, Antipyretic, Cytotoxic, Congestive enhancing, Gingival bleeding, Gastic ulcer, Hypotensive activity.

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Isolation of Crotepoxide From Berries of Croton Macrostachyus and Evaluation of Its Anti-Leishmanial Activity

Journal: Journal of Pharmacognosy and Phytochemistry

Author: Habtamu Gelaw, Legesse Adane*, Yinebeb Tariku, Asrat Hailu

Abstract: The chloroform extract of the berries of Croton macrostachyus was subjected to column chromatography with chloroform: ethyl acetate mixture as eluting solvent that led to isolation of Crotepoxide. Evaluation of antleishmanial activity of crotepoxide against promatigotes and amastigotes form of L. aethiopicashowed that the compound is less active as compared to the reference antileishamnial drugs (amphotericin B and miltefosine). Regardless of the observed activity, further in vivo tests are recommended before drawing any conclusion about the potential of the compound as a new antileishamnial drug candidate. 

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Recent Trends of Phytosomes for Delivering Herbal Extract with Improved Bioavailability

Journal: Journal of Pharmacognosy and Phytochemistry

Author: Arijit Gandhi *, Avik Dutta , Avijit Pal , Paromita Bakshi

Abstract: In the recent days, most of the prevailing diseases and nutritional disorders are treated with natural medicines. The effectiveness of any herbal medication is dependent on the delivery of effective level of the therapeutically active compound. But a severe limitation exists in their bioavailability when administered orally or by topical applications. Phytosomes are recently introduced herbal formulations that are better absorbed and as a result produced better bioavailability and actions than the conventional phyto molecules or botanical extracts. Phytosomes are produced by a process whereby the standardized plant extract or its constituents are bound to phospholipids, mainly phosphatidylcholine producing a lipid compatible molecular complex. Phytosome exhibit better pharmacokinetic and pharmacodynamic profile than conventional herbal extracts. The present review represents the recent advances and applications of various standardized herbal extract phytosomes as a tool of drug delivery.

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Evaluation of Antimicrobial Activity of Crude Methanol Extract of Solanum nodiflorum Jacq (Solanaceae)

Journal: Journal of Pharmacognosy and Phytochemistry

Author: Ibrahim T. Babalola* , Esther A. Adelakun, Sadiq Y. Garba

Abstract: Ethno botanical survey of medicinal plants has always serve as a rich source of valuable information that has been transmitted through generations. Ethnomedical use of Solanum nodiflorum as claimed by traditional healers was investigated. The methanol extract of S. nodiflorum (whole plant) was screened in-vitro for antifungal and antibacterial activity using pathogenic strains that are implicated in man and animal diseases. The plant extract significantly inhibited the growth of infectious dermatophytes namely Candida albicans, Trichophyton tonsurans and Aspergillus flavus.  The extract effectively inhibited the growth of Staphylococcus aureus, Bacillus cereus, Salmonella paratyphie A, Pseudomonas aeruginosa and Proteus mirabilis, but inactive against klebsiella pneumoneae. Preliminary phytochemical screening of the plant extract revealed the presence of alkaloids, saponins, anthraquinones, cardiac glycosides. Tannins and flavonoids were not detected in the extract. Solanum nodiflorum possess broad spectrum antimicrobial activity.

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